Journal
SMALL
Volume 16, Issue 36, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201907650
Keywords
biotransformation; nanomaterials; nanotoxicology
Categories
Funding
- European Union [814530]
- Competence Center for Materials Science and Technology (CCMX)
- Swiss National Science Foundation [310030_169207]
- NanoScreen Materials Challenge
- Swiss National Science Foundation (SNF) [310030_169207] Funding Source: Swiss National Science Foundation (SNF)
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More than a decade has passed since the first concepts of predictive nanotoxicology were formulated. During this time, many advancements have been achieved in multiple disciplines, including the success stories of the fiber paradigm and the oxidative stress paradigm. However, important knowledge gaps are slowing down the development of predictive nanotoxicology and require a mutidisciplinary effort to be overcome. Among these gaps, understanding, reproducing, and modeling of nanomaterial biotransformation in biological environments is a central challenge, both in vitro and in silico. This dynamic and complex process is still a challenge for today's bioanalytics. This work explores and discusses selected approaches of the multidisciplinary efforts taken in the last decade and the challenges that remain unmet, in particular concerning nanomaterial biotransformation. It highlights some future advancements that, together, can help to understand such complex processes and accelerate the development of predictive nanotoxicology.
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