Journal
SMALL
Volume 16, Issue 16, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201905994
Keywords
hybrid architectures; matrilysin; nanobiosensors; optical sensing; sensing platforms; tumor detection
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Funding
- Australian Research Council [IC140100026]
- International Postgraduate Research Scholarship (IPRS)
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Early detection of cancer is likely to be one of the most effective means of reducing the cancer mortality rate. Hence, simple and ultra-quick methods for noninvasive detection of early-stage tumors are highly sought-after. In this study, a nanobiosensing platform with a rapid response time of nearly 30 s is introduced for the detection of matrilysin-the salivary gland cancer biomarker-with a limit of detection as low as 30 nm. This sensing platform is based on matrilysin-digestible peptides that bridge gold nanoparticle (AuNPs) cores (approximate to 30-50 nm) and carbon quantum dot (CDs) satellites (approximate to 9 nm). A stepwise synthesis procedure is used for self-assembly of AuNP-peptide-CDs, ensuring their long-term stability. The AuNP-peptide-CDs produce ideal optical signals, with noticeable fluorescence quenching effects. Upon peptide cleavage by matrilysin, CDs leave the surface of AuNPs, resulting in ultra-fast detectable violet and visible fluorescent signals.
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