Journal
SMALL
Volume 16, Issue 16, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201906922
Keywords
magnetic composites; magnetosomes; Magnetospirillum gryphiswaldense; nanoparticles; synthetic biology
Categories
Funding
- Deutsche Forschungsgemeinschaft [Schu 1080/9-2]
- European Research Council (ERC) under the European Union [692637]
- European Research Council (ERC) [692637] Funding Source: European Research Council (ERC)
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Their unique material characteristics, i.e. high crystallinity, strong magnetization, uniform shape and size, and the ability to engineer the enveloping membrane in vivo make bacterial magnetosomes highly interesting for many biomedical and biotechnological applications. In this study, a versatile toolkit is developed for the multifunctionalization of magnetic nanoparticles in the magnetotactic bacterium Magnetospirillum gryphiswaldense, and the use of several abundant magnetosome membrane proteins as anchors for functional moieties is explored. High-level magnetosome display of cargo proteins enables the generation of engineered nanoparticles with several genetically encoded functionalities, including a core-shell structure, magnetization, two different catalytic activities, fluorescence and the presence of a versatile connector that allows the incorporation into a hydrogel-based matrix by specific coupling reactions. The resulting reusable magnetic composite demonstrates the high potential of synthetic biology for the production of multifunctional nanomaterials, turning the magnetosome surface into a platform for specific versatile display of functional moieties.
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