Journal
SMALL
Volume 16, Issue 14, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202000363
Keywords
cancer therapy; iridium; photodynamic therapy; polymeric micelles; upconversion nanoparticles
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Funding
- National Natural Science Foundation of China [21601034, 21571033]
- Jiangsu Province Natural Science Foundation [BK20160664]
- Fundamental Research Funds for the Central Universities [2242019K40142, 2242019K40140]
- Qing-Lan project in Colleges and Universities of Jiangsu Province
- City University of Hong Kong [9610472]
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Iridium(III) complexes are potent candidates for photodynamic therapy. However, their clinical usage is impeded by their poor water solubility, high dark toxicity, and negligible absorption in near-infrared region (NIR region). Here, it is proposed to solve these challenges by developing an iridium(III) complexe-based polymeric micelle system. This system is self-assembled using an iridium(III) complex-containing amphiphilic block polymer. The upconversion nanoparticles are included in the polymeric micelles to permit NIR excitation. Compared with the nonformulated iridium(III) complexes, under NIR stimulation, this polymeric micelle system exhibits higher O-1(2) generation efficiency, negligible dark toxicity, excellent tumor-targeting ability, and synergistic phototherapy-chemotherapy effect both in vitro and in vivo.
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