Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 320, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2020.128249
Keywords
Camphor; AIE; Ratiometric probe; Ga3+; ATP; Bioimaging
Funding
- National Natural Science Foundation of China [31470592]
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In this work, an easily available fluorescent probe CPD with aggregation-induced emission (AIE) feature based on natural and renewable camphor was designed and synthesized via a simple Schiff-base reaction between diaminomaleonitrile and the newly synthesized fluorophore CP-CHO. The probe CPD could selectively sense Ga3+ over other metal ions (including Al3+ and In3+) through a ratiometric strategy, which was realized for the first time. Moreover, this Ga3+-specific probe was operable in a near-perfect aqueous solution, thereby holding promise for biology-related applications. After chelation with Ga3+ , the in situ generated CPD-Ga3+ (1:1) ensemble was subsequently employed as a selective fluorescent probe for ratiometric recognition of ATP over other anions. The probe CPD also displayed ultrafast and reversible fluorescence responses toward Ga3+ and ATP with low detection limits. Furthermore, a simple test strip-based portable detecting device and a combinatorial molecular logic circuit were established for improving its practical applicability. Additionally, the desirable sensing performances of CPD for Ga3+ and CPD-Ga3+ complex for ATP were successfully reconfirmed both in living HeLa cells and in living mice.
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