Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 309, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2020.127709
Keywords
Voltammetry; Functionalized graphene quantum dots; palladium@gold; Cancer; Early diagnosis
Funding
- National Key Research and Development Program of China [2018YFC1603001]
- National Natural Science Foundation of China [21576115]
- Science and Technology Department of Henan Province of China [192102210184]
- MOE [B13025]
- SAFEA [B13025]
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Determination of circulating cancer cells in human blood is potential to be convenient diagnosis of different cancers. The study reports one strategy for synthesis of folic acid and glutamic acid-functionalized graphene quantum dot-palladium@gold (FA/Glu-GQD-Pd@Au). Firstly, FA/Glu-GQD was prepared by thermolysis of the mixture of citric acid, glutamic acid and folic acid. Then, it was used as the stabilizer and reducer for synthesis of FA/Glu-GQD-Pd@Au. The resulting hybrid was employed as one redox probe for construction of electrochemical sensing platform for cancer cells. The study reveals that the FA/Glu-GQD-Pd@Au offers one core@shell nanostructure. Pd nanocube as the core was covered by gold nanocrystal as the shell. For the detection, Pd@Au gives high electrocatalytic activity due to its unique structure as well as combination with FA/Glu-GQD. FA/Glu-GQD strongly binds with cancer cells to produce target recognition. FA/Glu-GQD occurs reversible redox reactions on the electrode surface and produces electrochemical signal for binding cancer cells. Pd@Au in situ catalyzes redox of FA/Glu-GQD and achieves to significant signal amplification. The sensor based on FA/Glu-GQD-Pd@Au exhibits ultrahigh sensitivity for detection of cancer cells. The differential pulse voltammetric peak current linearly reduces with the increase of cancer cells in the range of 3-1 x 10(5) HepG2 cells mL(-1) with the detection limit of 2 cells mL(-1) (S/N = 3). The proposed analytical method has been successfully applied in electrochemical detection of circulating cancer cells in human blood.
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