Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 320, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2020.128044
Keywords
Fluorescent probes; SO2; Ratiometric; Viscosity; Imaging
Funding
- National Natural Science Foundation of China [21775096]
- Shanxi Province 1331 project key innovation team construction plan cultivation team [2018-CT-1]
- 2018 Xiangyuan County Solid Waste Comprehensive Utilization Science and Technology Project [2018XYSDJS-05]
- Shanxi Province Foundation for Returness [2017026]
- Shanxi Collaborative Innovation Center of High Value-added Utilization of Coal-related Wastes [2015-10-B3]
- Shanxi Province 2019 annual science and technology activities for overseas students selected funding projects
- Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [2019L0031]
- Key R&D Program of Shanxi Province [201903D421069]
- Scientific Instrument Center of Shanxi University [201512]
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Sulfur dioxide (SO2), as a signal molecule, has been proved to be involved in many physiological processes. However, its levels will be affected by all kinds of factors. Herein, we specially designed a ratiometric fluorescence probe (PS-1) for the detection of SO2. After responding to SO2, PS-1 showed an obvious enhancement from 1.68 to 168.3 of fluorescence emission ratios at 475 and 643 nm (I-475/I-643). Besides, we found PS-1 exhibited fast response (less 15 s) and low detection limit (17.7 nM), which means PS-1 can monitor a tiny concentration change of SO2 in the cell in real-time. Assuredly, we found that the ratiometric fluorescence changes of PS-1 in the cells pre-incubated with nystatin were more obvious than that of no treated cells. Furthermore, PS-1 was applied for imaging in mice models. These results predictability indicate that internal increasing viscosity can induce increase of sulfur dioxide concentration. Thus, PS-1 could be used to study the relationship between biological microenvironment and sulfur dioxide concentration.
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