Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 107, Issue -, Pages 63-71Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2020.05.001
Keywords
Pluripotent stem cells; Cyclin; Cyclin-dependent kinases; CDK inhibitor
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Funding
- Thailand Research Fund [RSA6280090]
- Siriraj Research Fund [R016234002, R016333015]
- Foundation for Cancer Care
- Siriraj Foundation [D003421]
- Faculty of Medicine Siriraj Hospital, Mahidol University
- National Science and Technology Development Agency (NSTDA) of Thailand
- Japan Science and Technology Agency
- National Institute of Allergy and Infectious Diseases of United States as part of the e-ASIA Joint Research Program (e-ASIA JRP)
- NSTDA [P-15-50208]
- Chalermphrakiat Grant, Faculty of Medicine Siriraj Hospital, Mahidol University
- NIH [P01 HL089471]
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Over the last 15 years connections between cell cycle control, maintenance of pluripotency, and control of cell fate decisions have been firmly established. With the emergence of powerful tools, such as highly-specific small molecule inhibitors for cyclin-dependent protein kinase (CDK) activity and single-cell imaging technologies, the mechanistic links between cyclins, CDKs and regulation in PSCs in mechanistic detail has been made possible. In this review, we discuss new developments that mechanistically link the CDK regulatory network to control of cell fate decisions, including maintenance of the pluripotent state. Overall, these findings have potential to impact the translational applications of stem cells in regenerative medicine, drug discovery and cancer treatment.
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