Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 107, Issue -, Pages 28-35Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2020.03.009
Keywords
Cancer; Cell cycle; Cell proliferation; Cyclin; Cyclin-dependent kinase
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Funding
- FPI fellowship from the Ministry of Science, Innovation and Universities (MICIU)
- AEI-MICIU/FEDER [RTI2018-095582-B-I00, RED2018-102723-T]
- iLUNG programme from the Comunidad de Madrid [B2017/BMD-3884]
- Severo Ochoa Center of Excellence (MINECO) [SEV-2015-0510]
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Proper progression throughout the cell division cycle depends on the expression level of a family of proteins known as cyclins, and the subsequent activation of cyclin-dependent kinases (Cdks). Among the numerous members of the mammalian cyclin family, only a few of them, cyclins A, B, C, D and E, are known to display critical roles in the cell cycle. These functions will be reviewed here with a special focus on their relevance in different cell types in vivo and their implications in human disease.
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