Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 63, Issue 9, Pages 1328-1336Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-019-1616-6
Keywords
ultrasound; nucleus accumbens; addiction; synaptic plasticity; brain stimulation
Categories
Funding
- National Natural Science Foundation of China [81527901, 81822017, 11534013, 11774371, 31771215]
- Youth Innovation Promotion Association CAS [2018393]
- Science and Technology Commission of Shanghai Municipality [18QA1403700, 18JC1420304, 18140901700]
- Shanghai Clinical Research Center for Mental Health [19MC1911100]
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Ultrasound stimulation is an emerging noninvasive option in treating neuropsychiatric disorders. The present study investigates the behavioral alterations resulting from ultrasound stimulation on the nucleus accumbens (NAc) in freely moving mice. Our results show that an acute ultrasound stimulation on the NAc, rather than the visual cortex or auditory cortex, led to a pronounced avoidance behavior, while repeated NAc ultrasound stimulation resulted in an obvious conditioned place aversion with changes in synaptic protein (GluA1/2 subunit) expression. Notably, NAc ultrasound stimulation suppressed the morphine-induced conditioned place preference. The results provide evidence that NAc ultrasound stimulation can be applied as a potential noninvasive therapeutic option in treating psychiatric disorders.
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