Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 64, Issue 1, Pages 66-76Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-020-1716-x
Keywords
HIV-1; nuclear entry; nuclear endocytosis-like
Categories
Funding
- Chinese Academy of Sciences [XDB29050100]
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Research suggests that HIV-1 may enter the nucleus through nuclear vesicles, revealing a new mechanism for HIV-1 nuclear entry and expanding our understanding of HIV-1 virology.
It is recognized that HIV-1 capsid cores are disassembled in the cytoplasm, releasing their genomes into the nucleus through nuclear pores, but there is also evidence showing the capsid (CA) exists in the nucleus. Whether HIV-1 enters the nucleus and how it enters the nucleus through the undersized nuclear pore remains mysterious. Based on multicolor labeling and real-time imaging of the viral and cellular components, our observations via light and electron microscopy suggest that HIV-1 selectively gathered at the microtubule organization center (MTOC), leading the nearby nuclear envelope (NE) to undergo deformation, invagination and restoration to form a nuclear vesicle in which the viral particles were wrapped; then, the inner membrane of the nuclear vesicle ruptured to release HIV-1 into the nucleus. This unexpected discovery expands our understanding of the complexity of HIV-1 nuclear entry, which may provide new insights to HIV-1 virology.
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