Journal
SCIENCE CHINA-CHEMISTRY
Volume 63, Issue 8, Pages 1153-1158Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-020-9737-y
Keywords
fluorescent probe; hypochlorous acid; imaging; solid tumor
Categories
Funding
- National Natural Science Foundation of China [21877013, 21671043]
- Initial Research Funds for Young Teachers of Donghua University
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Levels of reactive oxygen species (ROS) in cancer cells or in the tumor microenvironment differ noticeably from those in normal cells and cellular microenvironments because ROS play important roles in all aspects of tumor physiology. However, due to the lack of adequate tools, it is difficult to study the relationship between ROS, especially certain types of ROS (e.g., HOCl), and cancer. We report herein an HOCl-specific fluorescent probe, FDOCl-20, containing a thiocarbamide group as a receptor, for the visualization of HOCl in solid tumors in vivo. This probe displays high selectivity and sensitivity to HOCl, and is appropriate for use in acidic conditions, including the tumor microenvironment. Using FDOCl-20 as a tool, we can visualize HOCl in solid tumors in vivo. Importantly, the fluorescent intensity of FDOCl-20 is proportional to tumor volume. Thus, FDOCl-20 is a useful tool to investigate the relationship between HOCl and the physiological processes of tumors.
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