Journal
SCIENCE CHINA-CHEMISTRY
Volume 63, Issue 7, Pages 946-956Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-020-9723-9
Keywords
second near-infrared window; fluorescence imaging; phototherapy; phototheranostics; polycyclic naphthalenediimide
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Funding
- Jiangsu Provincial Key Research and Development Plan [BE2017741]
- Natural Science Foundation of Jiangsu Province [BK20180136, BK20160051]
- Jiangsu Provincial Medical Youth Talent [QNRC 2016121]
- Nanjing Foundation for Development of Science and Technology [2017sc512031, 201605042]
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Optical imaging and phototherapy in the second near-infrared window (NIR-II, 900-1700 nm) can reduce tissue auto-fluorescence and photon scattering, which facilitates higher spatial resolution and deeper tissue penetration depth for solid tumor theranostics. Herein, a polycyclic naphthalenediimide (NDI) based chromophore 13-amino-4,5-dibromo-2,7- di(dodecan-6-yl)-1H-isoquinolino[4,5,6-fgh]naphtho[1,8-bc][1,9]phenanthroline-1,3,6,8(2H,7H,9H)-tetraone (NDI-NA) was designed and synthesized. With large polycyclic pi-systems, NDI-NA molecule possesses broad near-infrared (NIR) absorption (maximum at 777 nm) and emission (maximum at 921 nm). By nanoprecipitation, NDI-NA nanoparticles (NPs) were formed in aqueous solution with J-aggregative state, which showed huge red-shift in both absorption spectrum (maximum at 904 nm) and emission spectrum (maximum at 1,020 nm), endowing NDI-NA NPs efficient NIR-II fluorescence imaging capability. Besides, the NPs present effective tumor-targeting capability in vivo based on the enhanced permeation and retention (EPR) effect. More importantly, NDI-NA NPs simultaneously have high photothermal conversion efficiency (30.8%) and efficient reactive oxygen species generation ability, making them remarkably phototoxic to cancer cells. The polycyclic chromophore based multifunctional NDI-NA NPs as NIR-II phototheranostic agents possess bright future for clinical NIR-II imaging-guided cancer phototherapy.
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