Journal
SCIENCE
Volume 367, Issue 6484, Pages 1340-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aay6690
Keywords
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Categories
Funding
- National Institutes of Health (NIH) Big Data to Knowledge (BD2K) Initiative, a cross-NIH partnership [U54 EB020403]
- Kavli Foundation
- National Health and Medical Research Council (NHMRC) [1158127]
- NHMRC Senior Research Fellowship [APP1103623, APP1173025]
- QIMR Berghofer Fellowship
- German Federal Ministry of Education and Science (BMBF) [FKZ 01EG940]
- German Research Foundation (DFG) [ER 155/6-1]
- BMBF through the Integrated Network IntegraMent under the e:Med Program [01ZX1314A]
- Swiss National Science Foundation [156791]
- Initiative and Networking Fund of the Helmholtz Association
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (H2020) [720270, 785907]
- NIH [U01 AG024904]
- Department of Defense ADNI [W81XWH-12-2-0012]
- National Institute on Aging (NIA)
- National Institute of Biomedical Imaging and Bioengineering
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc.
- Cogstate
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- EuroImmun
- Fujirebio
- Michael J. Fox Foundation (MJFF) [14848]
- Heinz Nixdorf Foundation (Germany)
- AbbVie
- Eisai Inc.
- BioClinica, Inc.
- F. Hoffmann-La Roche, Ltd.
- Genentech, Inc.
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research AMP
- Development, LLC.
- Johnson AMP
- Johnson Pharmaceutical Research AMP
- Development, LLC
- Lumosity
- Lundbeck
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer, Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Canadian Institutes of Health Research
- NIA [U24 AG21886, R03 AG054936]
- NLM [R01 LM012535]
- Wellcome [102215/2/13/2]
- UK Medical Research Council (MRC) [102215/2/13/2]
- 23andMe
- Australian NHMRC
- Pratt Foundation
- Ramsay Health Care
- Viertel Charitable Foundation
- Schizophrenia Research Institute (Australia)
- NSW Health
- Macquarie Group Foundation
- Neurobehavioral Genetics Unit
- NHMRC [1067137, 1147644, 1051672, 1121474, 628386, 1105825]
- Wallenberg Scholar grant from the Knut and Alice Wallenberg Foundation
- Torsten and Ragnar Soderbergs Foundation
- HelseVest RHF [911554]
- Bergen Research Foundation
- University of Bergen
- Dr Einar Martens Fund
- K.G. Jebsen Foundation
- Research Council of Norway [177458/V 50, 204966/F 20]
- Bayer Healthcare, AG
- [R01 MH116147]
- [R01 MH1161671]
- [P41 EB015922]
- [RF1 AG051710]
- [RF1 AG041915]
- [R56 AG058854]
- [R01 AG059874]
- [R01 MH117601]
- [R01MH118349]
- [R00MH102357]
- [R01 MH085772]
- BBSRC [BB/F019394/1] Funding Source: UKRI
- MRC [MR/N027558/1, MR/R024065/1, G0701120, MR/M013111/1, G0700704, MC_PC_19009, G1001245] Funding Source: UKRI
- National Health and Medical Research Council of Australia [1067137, 1121474, 1147644, 1158127] Funding Source: NHMRC
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The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
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