Journal
SCIENCE
Volume 368, Issue 6493, Pages 844-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aba5435
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Funding
- National Natural Science Foundation of China [31520103911, 31871610, 31901492]
- National Key Research and Development Program [2016YFD0100102-2]
- National Key Program on Transgenic Research from the Ministry of Agriculture of China [2016ZX08002003-002, 2016ZX08009-003]
- Agricultural Variety Improvement Project of Shandong Province [2019LZGC016]
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Fusarium head blight (FHB), a fungal disease caused by Fusarium species that produce food toxins, currently devastates wheat production worldwide, yet few resistance resources have been discovered in wheat germplasm. Here, we cloned the FHB resistance gene Fhb7 by assembling the genome of Thinopyrum elongatum, a species used in wheat distant hybridization breeding. Fhb7 encodes a glutathione S-transferase (GST) and confers broad resistance to Fusarium species by detoxifying trichothecenes through de-epoxidation. Fhb7 GST homologs are absent in plants, and our evidence supports that Th. elongatum has gained Fhb7 through horizontal gene transfer (HGT) from an endophytic Epichloe species. Fhb7 introgressions in wheat confers resistance to both FHB and crown rot in diverse wheat backgrounds without yield penalty, providing a solution for Fusarium resistance breeding.
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