Journal
SCIENCE
Volume 367, Issue 6484, Pages 1339-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aay5012
Keywords
-
Categories
Funding
- Wellcome [098051, 206194, 207492]
- Francis Crick Institute [FC001595]
- Cancer Research UK
- UK Medical Research Council
- Wellcome Trust [217223/Z/19/Z]
- European Research Council [852558]
- Gates Cambridge scholarship
- Estonian Research Council [PUT1036]
- Wellcome Trust [217223/Z/19/Z] Funding Source: Wellcome Trust
- European Research Council (ERC) [852558] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Genome sequences from diverse human groups are needed to understand the structure of genetic variation in our species and the history of, and relationships between, different populations. We present 929 high-coverage genome sequences from 54 diverse human populations, 26 of which are physically phased using linked-read sequencing. Analyses of these genomes reveal an excess of previously undocumented common genetic variation private to southern Africa, central Africa, Oceania, and the Americas, but an absence of such variants fixed between major geographical regions. We also find deep and gradual population separations within Africa, contrasting population size histories between hunter-gatherer and agriculturalist groups in the past 10,000 years, and a contrast between single Neanderthal but multiple Denisovan source populations contributing to present-day human populations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available