4.1 Letter

Synthesis of 4-(trifluoromethyl)pyrrolidines Containing Sulfonyl, Iminosulfonyl, Sulfamide, or Phosphonyl Substituent

Journal

CHEMISTRY OF HETEROCYCLIC COMPOUNDS
Volume 52, Issue 7, Pages 503-506

Publisher

SPRINGER
DOI: 10.1007/s10593-016-1916-5

Keywords

azomethine ylide; phosphonate; pyrrolidine; sulfamide; sulfone; sulfoximine; trifluoromethyl group; cycloaddition

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New 4-(trifluoromethyl)pyrrolidines containing sulfonyl, iminosulfonyl, sulfamide, or phosphonyl group at position 3 were synthesized by 1,3-dipolar cycloaddition reactions of 3,3,3-trifluoropropene derivatives to azomethine ylide generated in situ from N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine.

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