Journal
CHEMISTRY LETTERS
Volume 45, Issue 11, Pages 1259-1261Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.160687
Keywords
CO2 reduction; Viologen derivative; Artificial coenzyme
Categories
Funding
- Precursory Research for Embryonic Science and Technology (PRESTO, Japan Science and Technology Agency JST)
- [15K14239]
- [2406]
- Grants-in-Aid for Scientific Research [24107005, 15K14239] Funding Source: KAKEN
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Formate dehydrogenase (FDH) is an attractive biocatalyst for CO2 reduction. The reduced form of methylviologen acts as an artificial coenzyme for FDH. For further improvement in the CO2 reduction catalytic activity of FDH, a viologen derivative with two amino groups, 1,1'-diaminoethyl-4,4'-bipyridinium salt (DA(2+)), was synthesized as the effective artificial coenzyme for FDH. By enzyme kinetic analysis, the catalytic efficiency, i.e., k(cat)/K-m value of the reduced form of DA(2+) was estimated to be more than 560 times larger than that of NADH, the natural coenzyme for FDH.
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