Journal
CHEMISTRY LETTERS
Volume 45, Issue 8, Pages 982-984Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.160425
Keywords
Fluorescence sensing; RNA-binding ligand; Orphan guanine
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [16H04159, 15K13716]
- Grants-in-Aid for Scientific Research [16H04159, 15K13716] Funding Source: KAKEN
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We report on a fluorescent pteridine derivative modified with a guanidino group for the selective detection of an orphan guanine in RNA duplexes with a dissociation constant of 31 +/- 7 nM (pH 7.0, T = 20 degrees C). The significant effect of the guanidino group attached to the pteridine ring on the binding selectivity and affinity is discussed based on the examination of thermodynamic parameters.
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