Journal
CHEMISTRY LETTERS
Volume 45, Issue 8, Pages 964-966Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.160427
Keywords
C-F bond activation; Silver catalyst; Fluoroindole
Categories
Funding
- JSPS KAKENHI Grant [JP16H01002, JP16K20939]
- Grants-in-Aid for Scientific Research [16K13943, 16K20939, 16H01002, 16H04105] Funding Source: KAKEN
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An electrophilic 5-endo-trig cyclization of beta,beta-difluoro-o-sulfonamidostyrenes was performed in 1,1,1,3,3,3-hexafluoropropan-2-ol using a Ag(I) catalyst and N,O-bis(trimethylsilyl)acetamide. In this process, vinylic C-F bond activation was achieved via silver-catalyzed beta-fluorine elimination, accompanied by C-N bond formation, which led to the synthesis of 2-fluoroindoles.
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