Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 197, Issue -, Pages 33-44Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2015.07.025
Keywords
Ceramides; Autophagy; Resveratrol; Fenretinide
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Funding
- Ministerio de Ciencia e Innovacion, Spain [SAF2011-22444, CTQ2014-54743-R]
- Fundacio Marato TV3 [112130, 112132]
- SENESCYT-Ecuador
- MINECO
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Dihydroceramide desaturase (Des1) is the last enzyme in the de novo synthesis of ceramides (Cer). It catalyzes the insertion of a double bond into dihydroceramides (dhCer) to convert them to Cer, both of which are further metabolized to more complex (dihydro) sphingolipids. For many years dhCer have received poor attention, mainly due to their supposed lack of biological activity. It was not until about ten years ago that the concept that dhCer might have regulatory roles in biology emerged for the first time. Since then, multiple publications have established that dhCer are implicated in a wide spectrum of biological processes. Physiological and pathophysiological functions of dhCer have been recently reviewed. In this review we will focus on the biochemical features of Des1 and on its inhibition by different compounds with presumably different modes of action. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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