Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 199, Issue -, Pages 136-143Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2016.05.003
Keywords
Cholesterol; Membrane fusion; Virus entry; Exocytosis; Fusion protein; Fusion peptide; SNARE; Viral envelope protein
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Funding
- NIH [P01 GM72694, R01 AI30557]
- Human Frontier Science Program [RGP0055/2015]
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Cholesterol modulates the bilayer structure of biological membranes in multiple ways. It changes the fluidity, thickness, compressibility, water penetration and intrinsic curvature of lipid bilayers. In multi component lipid mixtures, cholesterol induces phase separations, partitions selectively between different coexisting lipid phases, and causes integral membrane proteins to respond by changing conformation or redistribution in the membrane. But, which of these often overlapping properties are important for membrane fusion? Here we review a range of recent experiments that elucidate the multiple roles that cholesterol plays in SNARE-mediated and viral envelope glycoprotein-mediated membrane fusion. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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