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The role of the gut microbiota in the pathophysiology of mental and neurological disorders

Journal

PSYCHIATRIC GENETICS
Volume 30, Issue 4, Pages 87-100

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YPG.0000000000000255

Keywords

Alzheimer; anxiety; autism; bipolar disorder; depression; mental disorders; microbiota-gut-brain axis; neurological disorders; Parkinson; schizophrenia

Funding

  1. European Union [712949]
  2. Agency for Business Competitiveness of the Government of Catalonia
  3. Catalan Government
  4. Marie Curie Actions (MSCA) [712949] Funding Source: Marie Curie Actions (MSCA)

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In recent decades, the concept of the gut microbiota as a potential novel therapeutic strategy for mental health has emerged. The tiny microbes inhabiting our gut communicate through a bidirectional communication signaling with the brain that influences gut physiology, brain function and behavior. Accumulating evidence suggests that perturbation of the gut microbiota contributes to the pathophysiology of mental illnesses including autism, depression and anxiety as well as neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. This review will highlight recent findings in both human and animal studies indicating how changes in the gut microbiota can impact the pathophysiology of such diseases. The current work will also provide an understanding of the efficacy of microbiota-targeted therapies on psychiatric disorders. Copyright (C) 2020 Wolters Kluwer Health, Inc. All rights reserved.

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