Journal
PROGRESS IN RETINAL AND EYE RESEARCH
Volume 79, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2020.100865
Keywords
Central serous chorioretinopathy (CSC); Choroid; Retinal pigment epithelium (RPE); Corticosteroids; Choroidal endothelial cells (CECs); Complement factor H (CFH); Pachychoroid; Hyperpermeability; Mineralocorticoids; Eplerenone
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Funding
- NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust
- UCL Institute of Ophthalmology
- NIHR
- GCRF UKRI [MR/P207881/1]
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Central serous chorioretinopathy (CSC) is a common form of vision loss, typically seen in working-age men. The pathophysiology behind CSC still eludes us, however significant advances have been made in understanding this disease over the last decade using information from genetic and cell-based studies and imaging modalities. This review aims to give an overview of the current pathophysiology hypotheses surrounding CSC in addition to future directions in cellular work from human induced pluripotent stem cell derived choroidal endothelial cells from CSC patients. Furthermore, this review will provide the reader with an update on the clinical aspects of CSC including risk factors, diagnostic challenges and findings from multimodal imaging.
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