Journal
PROGRESS IN LIPID RESEARCH
Volume 78, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2020.101034
Keywords
Maresin-1; Nuclear receptor; G protein-coupled receptor; Inflammation; Resolution; LGR6; ROR alpha
Funding
- Basic Science Research Program of the Korean National Research Foundation - Korean Ministry of Education, Science and Technology [NRF-2019R1A2C1005523]
- Medical Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF- 2017R1A5A2014768]
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Maresin-1, a pro-resolving lipid mediator, is drawing a great deal of attention in receptor pharmacology, largely because two distinct types of receptor molecules have been reported as the targets of maresin-1. One is retinoic acid-related orphan receptor alpha (ROR alpha) and the other is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6). ROR alpha is a nuclear receptor and LGR6 is a plasma membrane GPCR. Identification of two different molecular targets raises the following question: What are the pro-resolving functions of each receptor in inflammation resolution, host defense, tissue homeostasis, and wound healing? In this article, I review the new targets from the point of view of pharmacology and maresin-1 resolution along with intracellular signaling molecules.
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