Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 13, Pages 7001-7003Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2002589117
Keywords
coronavirus; SARS-CoV-2; VeroE6; outbreak; TMPRSS2
Categories
Funding
- Japan Agency for Medical Research and Development [JP19fk0108104, JP19fk0108030j0403, JP19fk0108058j0802, 19fk0108111j0001]
- Japan Society for the Promotion of Science [17K08868, 18H02665]
- Grants-in-Aid for Scientific Research [18H02665, 17K08868] Funding Source: KAKEN
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A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2-expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.
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