Related references
Note: Only part of the references are listed.De novo design of potent and selective mimics of IL-2 and IL-15
Daniel-Adriano Silva et al.
NATURE (2019)
A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism
Eleonora Trotta et al.
NATURE MEDICINE (2018)
Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy
Jamie B. Spangler et al.
JOURNAL OF IMMUNOLOGY (2018)
Probing conformational dynamics in biomolecules via chemical exchange saturation transfer: a primer
Pramodh Vallurupalli et al.
JOURNAL OF BIOMOLECULAR NMR (2017)
Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2
Natalia Arenas-Ramirez et al.
Science Translational Medicine (2016)
Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms
Jamie B. Spangler et al.
IMMUNITY (2015)
Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps
Suman Mitra et al.
IMMUNITY (2015)
Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy
Wei Liao et al.
IMMUNITY (2013)
NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers
Ashok Sekhar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases
Sean K. Whittier et al.
SCIENCE (2013)
Conformational Selection or Induced Fit? A Critical Appraisal of the Kinetic Mechanism
Austin D. Vogt et al.
BIOCHEMISTRY (2012)
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
Aron M. Levin et al.
NATURE (2012)
The role of interleukin-2 during homeostasis and activation of the immune system
Onur Boyman et al.
NATURE REVIEWS IMMUNOLOGY (2012)
Stereospecific Isotopic Labeling of Methyl Groups for NMR Spectroscopic Studies of High-Molecular-Weight Proteins
Pierre Gans et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Effect of in vitro-expanded CD4+CD25+Foxp3+ regulatory T cell therapy combined with lymphodepletion in murine skin allotransplantation
Youn-Hee Park et al.
CLINICAL IMMUNOLOGY (2010)
Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity
Thomas R. Malek et al.
IMMUNITY (2010)
Methyl groups as probes of supra-molecular structure, dynamics and function
Amy M. Ruschak et al.
JOURNAL OF BIOMOLECULAR NMR (2010)
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
Yenkel Grinberg-Bleyer et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor α subunit CD25
Sven Letourneau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
Kylie E. Webster et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Conformational selection or induced fit: A flux description of reaction mechanism
Gordon G. Hammes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
Qizhi Tang et al.
IMMUNITY (2008)
Intrinsic motions along an enzymatic reaction trajectory
Katherine A. Henzler-Wildman et al.
NATURE (2007)
A single-quantum methyl 13C-relaxation dispersion experiment with improved sensitivity
Patrik Lundstrom et al.
JOURNAL OF BIOMOLECULAR NMR (2007)
Quantitative dynamics and binding studies of the 20S proteasome by NMR
Remco Sprangers et al.
NATURE (2007)
Hot-spot mimicry of a cytokine receptor by a small molecule
Christopher D. Thanos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The dynamic energy landscape of dihydrofolate reductase catalysis
David D. Boehr et al.
SCIENCE (2006)
Selective stimulation of T cell subsets with antibody-cytokine immune complexes
O Boyman et al.
SCIENCE (2006)
Structure of the quaternary complex of interleukin-2 with its α, β, and γc receptors
XQ Wang et al.
SCIENCE (2005)
Tolerance, not immunity, crucially depends on IL-2
TR Malek et al.
NATURE REVIEWS IMMUNOLOGY (2004)
Methyl TROSY: explanation and experimental verification
JE Ollerenshaw et al.
MAGNETIC RESONANCE IN CHEMISTRY (2003)
Binding of small molecules to an adaptive protein-protein interface
MR Arkin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Share Paper
