Journal
CHEMISTRY & BIODIVERSITY
Volume 13, Issue 9, Pages 1186-1193Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201600012
Keywords
Fungus; Peyronellaea glomerata; Isocoumarin; Peyroisocoumarins A - D; ARE luciferase activation
Funding
- National Basic Research Program [2015CB755906]
- NSFC-Shangdong Join Fund for Marine Science [U1406402]
- COMRA [DY125-15-T-01]
- Sino-German Project [GZ816]
- National Natural Science Foundation of China [41376127]
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Chemical examination of the solid culture of the sponge-associated fungus Peyronellaea glomerata led to the isolation of five new isocoumarins, namely peyroisocoumarins A-D (1-4) and isocitreoisocoumarinol (5), together with 13 known analogues (6-18). Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher's method for the configurational assignments. Peyroisocoumarins A and B were characterized by the presence of Cl-atom at pentane chain, which were unusual in isocoumarin derivatives. The ARE reporter assay revealed that peyroisocoumarins A, B, and D exerted potent ARE activation in HepG2C8 cells, while the preliminary analyses of structure-activity relationship was discussed.
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