Journal
POLYMER JOURNAL
Volume 52, Issue 8, Pages 977-983Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41428-020-0342-9
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Funding
- GAP FUND Project (4th period in 2018) from Kyoto University
- Takeda Science Foundation
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Preoperative marking or tattooing is performed in clinical situations using an India ink to identify gastrointestinal lesions. However, diffusion of the carbon particles from the ink results in unclear marking. We observed that subcutaneously injected sodium alginate solutions formed a gel and prevented the diffusion of carbon particles into the tissues of mice. Similar results were observed in resected porcine large intestines. The tattooed area was well correlated with the molecular weight and viscosity of sodium alginate, indicating that an adequately viscous sodium alginate hydrogel is useful for clear marking.
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