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Ubaldo Armato et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)
New potent calcimimetics: II. Discovery of benzothiazole trisubstituted ureas
Pierre Deprez et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
The calcium-sensing receptor is silenced by genetic and epigenetic mechanisms in unfavorable neuroblastomas and its reactivation induces ERK1/2-dependent apoptosis
Carla Casala et al.
CARCINOGENESIS (2013)
Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor
Eleftheria Diakogiannaki et al.
DIABETOLOGIA (2013)
Impact of Clinically Relevant Mutations on the Pharmacoregulation and Signaling Bias of the Calcium-Sensing Receptor by Positive and Negative Allosteric Modulators
Katie Leach et al.
ENDOCRINOLOGY (2013)
Identification of AP2S1 Mutation and Effects of Low Calcium Formula in an Infant With Hypercalcemia and Hypercalciuria
Yasuko Fujisawa et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)
Hypothermia and Pharmacological Regimens that Prevent Overexpression and Overactivity of the Extracellular Calcium-Sensing Receptor Protect Neurons against Traumatic Brain Injury
Jong Youl Kim et al.
JOURNAL OF NEUROTRAUMA (2013)
The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule
Giovambattista Capasso et al.
KIDNEY INTERNATIONAL (2013)
Calcium Sensing Receptor Absence Delays Postnatal Brain Development via Direct and Indirect Mechanisms
Xiu-Ling Liu et al.
MOLECULAR NEUROBIOLOGY (2013)
Structural mechanism of ligand activation in human GABAB receptor
Yong Geng et al.
NATURE (2013)
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Andrew C. Kruse et al.
NATURE (2013)
Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3
M. Andrew Nesbit et al.
NATURE GENETICS (2013)
OPINION Signalling bias in new drug discovery: detection, quantification and therapeutic impact
Terry Kenakin et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Neonatal Hypercalcemia due to a Homozygous Mutation in the Calcium-Sensing Receptor: Failure of Cinacalcet
Eduardo Garcia Soblechero et al.
NEONATOLOGY (2013)
Germline Mutations Affecting Gα11 in Hypoparathyroidism
Michael Mannstadt et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Mutations Affecting G-Protein Subunit α11 in Hypercalcemia and Hypocalcemia
M. Andrew Nesbit et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Polymorphisms in the Calcium-Sensing Receptor Gene Are Associated with Clinical Outcome of Neuroblastoma
Laia Masvidal et al.
PLOS ONE (2013)
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells
Maja S. Engelstoft et al.
MOLECULAR METABOLISM (2013)
Pharmacology of AMG 416 (Velcalcetide), a Novel Peptide Agonist of the Calcium-Sensing Receptor, for the Treatment of Secondary Hyperparathyroidism in Hemodialysis Patients
Sarah Walter et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Effects of Cinacalcet in Renal Transplant Patients with Hyperparathyroidism
Marie Courbebaisse et al.
AMERICAN JOURNAL OF NEPHROLOGY (2012)
Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system
Sam X. Cheng
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)
The Calcium-Sensing Receptor Beyond Extracellular Calcium Homeostasis: Conception, Development, Adult Physiology, and Disease
Daniela Riccardi et al.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 74 (2012)
Pharmacodynamic Responses to combined treatment regimens with the calcium sensing receptor antagonist JTT-305/MK-5442 and alendronate in osteopenic ovariectomized rats
John E. Fisher et al.
BONE (2012)
Biased agonism of the calcium-sensing receptor
Alex Rojas Bie Thomsen et al.
CELL CALCIUM (2012)
Regulation of calcium in pancreatic α- and β-cells in health and disease
Patrik Rorsman et al.
CELL CALCIUM (2012)
Calcium-Sensing Receptor Activation Increases Cell-Cell Adhesion and β-Cell Function
Claire E. Hills et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2012)
Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies
B. Trzaskowski et al.
CURRENT MEDICINAL CHEMISTRY (2012)
Ex vivo calcium percutaneous eggression in normal and tape-stripped human skin
Elsa Jungman et al.
CUTANEOUS AND OCULAR TOXICOLOGY (2012)
Identification of Molecular Phenotypes and Biased Signaling Induced by Naturally Occurring Mutations of the Human Calcium-Sensing Receptor
Katie Leach et al.
ENDOCRINOLOGY (2012)
Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor
Anna E. Davey et al.
ENDOCRINOLOGY (2012)
Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites
Fadil M. Hannan et al.
HUMAN MOLECULAR GENETICS (2012)
Large Putative PEST-like Sequence Motif at the Carboxyl Tail of Human Calcium Receptor Directs Lysosomal Degradation and Regulates Cell Surface Receptor Level
Xiaolei Zhuang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Negative Cross-talk between Calcium-sensing Receptor and β-Catenin Signaling Systems in Colonic Epithelium
Osvaldo Rey et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Ronacaleret, a calcium-sensing receptor antagonist, increases trabecular but not cortical bone in postmenopausal women
Lorraine A. Fitzpatrick et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2012)
Parathyroid Hormone-Related Protein: An Update
John J. Wysolmerski
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)
PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor
Alexandre Loupy et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Ablation of the Calcium-Sensing Receptor in Keratinocytes Impairs Epidermal Differentiation and Barrier Function
Chia-Ling Tu et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)
Distribution and regulation of the 25-hydroxyvitamin D3 1α-hydroxylase in human parathyroid glands
Cynthia S. Ritter et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2012)
Deficiency of the Calcium-Sensing Receptor in the Kidney Causes Parathyroid Hormone-Independent Hypocalciuria
Hakan R. Toka et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)
Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation
Khalil Kass Youssef et al.
NATURE CELL BIOLOGY (2012)
Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2
Yong Geng et al.
NATURE NEUROSCIENCE (2012)
Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis
Glenn M. Chertow et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Calcium-Sensing Receptor and Aquaporin 2 Interplay in Hypercalciuria-Associated Renal Concentrating Defect in Humans. An In Vivo and In Vitro Study
Giuseppe Procino et al.
PLOS ONE (2012)
Strontium Is a Biased Agonist of the Calcium-Sensing Receptor in Rat Medullary Thyroid Carcinoma 6-23 Cells
Alex Rojas Bie Thomsen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor
Yu Wang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2011)
The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells
Alice P. Liou et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2011)
Ronacaleret, a calcium-sensing receptor antagonist, has no significant effect on radial fracture healing time: Results of a randomized, double-blinded, placebo-controlled Phase II clinical trial
Lorraine A. Fitzpatrick et al.
BONE (2011)
Vascular actions of calcimimetics: role of Ca2+-sensing receptors versus Ca2+ influx through L-type Ca2+ channels
Pratish Thakore et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
BRCA1 suppresses the expression of survivin and promotes sensitivity to paclitaxel through the calcium sensing receptor (CaSR) in human breast cancer cells
Moltira Promkan et al.
CELL CALCIUM (2011)
Shh signalling restricts the expression of Gcm2 and controls the position of the developing parathyroids
Armelle Grevellec et al.
DEVELOPMENTAL BIOLOGY (2011)
Calcitropic Hormones and IGF-I Are Influenced by Dietary Protein
Victor Dubois-Ferriere et al.
ENDOCRINOLOGY (2011)
A novel mutation of the primary protein kinase C phosphorylation site in the calcium-sensing receptor causes autosomal dominant hypocalcemia
Syndia Lazarus et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2011)
Polymorphisms at the regulatory regions of the CASR gene influence stone risk in primary hyperparathyroidism
Giuseppe Vezzoli et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2011)
Enteric Neuronal Density Contributes to the Severity of Intestinal Inflammation
Kara Gross Margolis et al.
GASTROENTEROLOGY (2011)
Allosteric Modulation of the Calcium-sensing Receptor by γ-Glutamyl Peptides INHIBITION OF PTH SECRETION, SUPPRESSION OF INTRACELLULAR cAMP LEVELS, AND A COMMON MECHANISM OF ACTION WITH L-AMINO ACIDS
Geoffrey K. Broadhead et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
An Akt-dependent Increase in Canonical Wnt Signaling and a Decrease in Sclerostin Protein Levels Are Involved in Strontium Ranelate-induced Osteogenic Effects in Human Osteoblasts
Mark S. Rybchyn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Osteoblast Extracellular Ca2+-Sensing Receptor Regulates Bone Development, Mineralization, and Turnover
Melita M. Dvorak-Ewell et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2011)
Autoimmune Hypocalciuric Hypercalcemia Unresponsive to Glucocorticoid Therapy in a Patient with Blocking Autoantibodies against the Calcium-Sensing Receptor
J. Carl Pallais et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
Neonatal Hyperparathyroidism with a Heterozygous Calcium-Sensing Receptor (CASR) R185Q Mutation: Clinical Benefit from Cinacalcet
Christina M. S. Reh et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
The Effects of Ronacaleret, a Calcium-Sensing Receptor Antagonist, on Bone Mineral Density and Biochemical Markers of Bone Turnover in Postmenopausal Women with Low Bone Mineral Density
Lorraine A. Fitzpatrick et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
Mouse models for inherited endocrine and metabolic disorders
Sian E. Piret et al.
JOURNAL OF ENDOCRINOLOGY (2011)
Discovery of a Calcimimetic with Differential Effects on Parathyroid Hormone and Calcitonin Secretion
Charles Henley et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Characterization of Highly Efficacious Allosteric Agonists of the Human Calcium-Sensing Receptor
Jian-Nong Ma et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Regulator of G Protein Signaling 5 Is Highly Expressed in Parathyroid Tumors and Inhibits Signaling by the Calcium-Sensing Receptor
James Koh et al.
MOLECULAR ENDOCRINOLOGY (2011)
Agonist-Driven Maturation and Plasma Membrane Insertion of Calcium-Sensing Receptors Dynamically Control Signal Amplitude
Michael P. Grant et al.
SCIENCE SIGNALING (2011)
Extracellular calcium-sensing receptor inhibition of intestinal epithelial TNF signaling requires CaSR-mediated Wnt5a/Ror2 interaction
Jacqueline C. Kelly et al.
FRONTIERS IN PHYSIOLOGY (2011)
Penta-substituted benzimidazoles as potent antagonists of the calcium-sensing receptor (CaSR-antagonists)
Marc Gerspacher et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
The Epidermal Ca2+ Gradient: Measurement Using the Phasor Representation of Fluorescent Lifetime Imaging
A. Celli et al.
BIOPHYSICAL JOURNAL (2010)
An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation
Sanjay Kumar et al.
BONE (2010)
The calcium-sensing receptor in bone cells: A potential therapeutic target in osteoporosis
Pierre J. Marie
BONE (2010)
Calcium Sensing Receptor Mutations Implicated in Pancreatitis and Idiopathic Epilepsy Syndrome Disrupt an Arginine-rich Retention Motif
Ann Stepanchick et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2010)
A homozygous inactivating calcium-sensing receptor mutation, Pro339Thr, is associated with isolated primary hyperparathyroidism: correlation between location of mutations and severity of hypercalcaemia
Fadil M. Hannan et al.
CLINICAL ENDOCRINOLOGY (2010)
Novel Ca receptor signaling pathways for control of renal ion transport
Chunfa Huang et al.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2010)
Involvement of the Calcium-sensing Receptor in Human Taste Perception
Takeaki Ohsu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Increased Receptor Stimulation Elicits Differential Calcium-sensing ReceptorT888 Dephosphorylation
Wanda D. McCormick et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Novel Activating Mutations of the Calcium-Sensing Receptor: The Calcilytic NPS-2143 Mitigates Excessive Signal Transduction of Mutant Receptors
Saskia Letz et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)
The calcium-sensing receptor couples to Gαs and regulates PTHrP and ACTH secretion in pituitary cells
Ramanaiah Mamillapalli et al.
JOURNAL OF ENDOCRINOLOGY (2010)
Beneficial effect of cinacalcet in a child with familial hypocalciuric hypercalcemia
Uri S. Alon et al.
PEDIATRIC NEPHROLOGY (2010)
Broad-spectrum amino acid-sensing class C G-protein coupled receptors: Molecular mechanisms, physiological significance and options for drug development
Arthur D. Conigrave et al.
PHARMACOLOGY & THERAPEUTICS (2010)
Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion
Jianying Feng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Analysis and prediction of calcium-binding pockets from apo-protein structures exhibiting calcium-induced localized conformational changes
Xue Wang et al.
PROTEIN SCIENCE (2010)
Evidence Supporting a Role for the Calcium-Sensing Receptor in Alzheimer Disease
Yvette P. Conley et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2009)
The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion
Lakshmi Kantham et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
The Functions and Roles of the Extracellular Ca2+-Sensing Receptor along the Gastrointestinal Tract
John P. Geibel et al.
ANNUAL REVIEW OF PHYSIOLOGY (2009)
Multiple Ca2+-Binding Sites in the Extracellular Domain of the Ca2+-Sensing Receptor Corresponding to Cooperative Ca2+ Response
Yun Huang et al.
BIOCHEMISTRY (2009)
Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists
Mary T. Didiuk et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Involvement of both GPRC6A and the calcium-sensing receptor in strontium ranelate-induced osteoclastogenic signal expression and replication in primary human osteoblasts
M. S. Rybchyn et al.
BONE (2009)
Molecular basis for amino acid sensing by family C G-protein-coupled receptors
P. Wellendorph et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Osteoblasts play key roles in the mechanisms of action of strontium ranelate
T. C. Brennan et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
The Calcium-Sensing Receptor and Parathyroid Hormone-related Protein Are Expressed in Differentiated, Favorable Neuroblastic Tumors
Carmen de Torres et al.
CANCER (2009)
Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells
Masih-ul Alam et al.
CARDIOVASCULAR RESEARCH (2009)
Calcium sensing receptor down-regulates malignant cell behavior and promotes chemosensitivity in human breast cancer cells
Guangming Liu et al.
CELL CALCIUM (2009)
Extracellular calcium promotes the migration of breast cancer cells through the activation of the calcium sensing receptor
Zuzana Saidak et al.
EXPERIMENTAL CELL RESEARCH (2009)
Glial Cells Missing-2 (GCM2) Transactivates the Calcium-Sensing Receptor Gene: Effect of a Dominant-Negative GCM2 Mutant Associated With Autosomal Dominant Hypoparathyroidism
Lucie Canaff et al.
HUMAN MUTATION (2009)
The Calcium-sensing Receptor Is Involved in Strontium Ranelate-induced Osteoclast Apoptosis NEW INSIGHTS INTO THE ASSOCIATED SIGNALING PATHWAYS
Anne S. Hurtel-Lemaire et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Calcium-Sensing Receptor Expression Is Regulated by Glial Cells Missing-2 in Human Parathyroid Cells
Masahide Mizobuchi et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2009)
A Novel Loss-of-Function Mutation, Gln459Arg, of the Calcium-Sensing Receptor Gene Associated with Apparent Autosomal Recessive Inheritance of Familial Hypocalciuric Hypercalcemia
Steven A. Lietman et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)
Long-Term Oral Polyamine Intake Increases Blood Polyamine Concentrations
Kuniyasu Soda et al.
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY (2009)
Effect of the Calcimimetic R-568 [3-(2-Chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on Correcting Inactivating Mutations in the Human Calcium-Sensing Receptor
Jenny Ying Lin Lu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
The Calcium-Sensing Receptor Promotes Urinary Acidification to Prevent Nephrolithiasis
Kirsten Y. Renkema et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)
Pharmacochaperone-Mediated Rescue of Calcium-Sensing Receptor Loss-of-Function Mutants
Elissa White et al.
MOLECULAR ENDOCRINOLOGY (2009)
Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants
L. Ceglia et al.
OSTEOPOROSIS INTERNATIONAL (2009)
Acute cardiovascular effects of the calcimimetic R-568 and its enantiomer S-568 in rats
Kumiko Nakagawa et al.
PEDIATRIC NEPHROLOGY (2009)
Towards predicting Ca2+-binding sites with different coordination numbers in proteins with atomic resolution
Xue Wang et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2009)
An idiopathic epilepsy syndrome linked to 3q13.3-q21 and missense mutations in the extracellular calcium sensing receptor gene
Ashish Kapoor et al.
ANNALS OF NEUROLOGY (2008)
Dietary protein and bone health: Roles of amino acid-sensing receptors in the control of calcium metabolism and bone homeostasis
A. D. Conigrave et al.
ANNUAL REVIEW OF NUTRITION (2008)
Regulation of GPCRs by Endocytic membrane trafficking and its potential implications
Ayfin C. Hanyaloglu et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2008)
Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro
Edith Bonnelye et al.
BONE (2008)
A Role for the Extracellular Calcium-Sensing Receptor in Cell-Cell Communication in Pancreatic Islets of Langerhans
Isidora Kitsou-Mylona et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2008)
Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells
Ramanaiah Mamillapalli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Statistical analysis of structural characteristics of protein Ca2+-binding sites
Michael Kirberger et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2008)
Novel Inactivating Mutations of the Calcium-Sensing Receptor: The Calcimimetic NPS R-568 Improves Signal Transduction of Mutant Receptors
Ramona Rus et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)
The calcium-sensing receptor and insulin secretion: a role outside systemic control 15 years on
M. N. Hodgkin et al.
JOURNAL OF ENDOCRINOLOGY (2008)
Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis
Tara I. Ellison et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)
Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: Potential impact on reduced myelin basic protein in CaR-null mice
Naibedya Chattopadhyay et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2008)
Cinacalcet suppresses calcification of the aorta and heart in uremic rats
Takehisa Kawata et al.
KIDNEY INTERNATIONAL (2008)
A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex
Bernard T. Kelly et al.
NATURE (2008)
Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor
Thomas N. Vizard et al.
NATURE NEUROSCIENCE (2008)
Structural diversity of G protein-coupled receptors and significance for drug discovery
Malin C. Lagerstrom et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Improved model building and assessment of the Calcium-sensing receptor transmembrane domain
Lintao Bu et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2008)
The Extracellular Calcium-Sensing Receptor (CaSR) Is a Critical Modulator of Skeletal Development
Wenhan Chang et al.
SCIENCE SIGNALING (2008)
Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes
Chia-Ling Tu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: A mechanism for calcium-regulated calcium transport into milk
Joshua N. VanHouten et al.
ENDOCRINOLOGY (2007)
Transcellular calcium transport in mammary epithelial cells
Joshua N. VanHouten et al.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2007)
Calcimimetic, AMG 073, induces relaxation on isolated rat aorta
Sanela Smajilovic et al.
VASCULAR PHARMACOLOGY (2007)
Type B γ-aminobutyric acid receptors modulate the function of the extracellular Ca2+-Sensing receptor and cell differentiation in murine growth plate Chondrocytes
Zhiqiang Cheng et al.
ENDOCRINOLOGY (2007)
Inference of macromolecular assemblies from crystalline state
Evgeny Krissinel et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Complex formation with the type B γ-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor -: Studies with hek-293 cells and neurons
Wenhan Chang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
HIPK2 represses β-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis
Guangwei Wei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology
Katie Leach et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2007)
Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone
Melita M. Dvorak et al.
ENDOCRINOLOGY (2007)
Identification and dissection of Ca2+-binding sites in the extracellular domain of Ca2+-sensing receptor
Yun Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
α-klotho as a regulator of calcium homeostasis
Akihiro Imura et al.
SCIENCE (2007)
Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism
Alma P. Reyes-Ibarra et al.
MOLECULAR ENDOCRINOLOGY (2007)
Aromatic L-amino acids activate the calcium-sensing receptor
Arthur D. Conigrave et al.
JOURNAL OF NUTRITION (2007)
Protein kinase C-mediated phosphorylation of the calcium-sensing receptor is stimulated by receptor activation and attenuated by calyculin-sensitive phosphatase activity
Sarah L. Davies et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Allosteric activation of the extracellular Ca2+-sensing receptor by L-amino acids enhances ERK1/2 phosphorylation
Heather J. Lee et al.
BIOCHEMICAL JOURNAL (2007)
Functional desensitization of the extracellular calcium-sensing receptor is regulated via distinct mechanisms:: Role of G protein-coupled receptor kinases, protein kinase C and β-arrestins
Stephan Lorenz et al.
ENDOCRINOLOGY (2007)
Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis
Ying Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations
Noriko Makita et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Takanori Muto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The extracellular calcium-sensing receptor reciprocally regulates the secretion of BMP-2 and the BMP antagonist Noggin in colonic myofibroblasts
Dinithi Peiris et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism
Jurgen Schauber et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Parathyroid-specific double knockout of G(q) and G(11) alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+-sensing receptor
Nina Wettschureck et al.
MOLECULAR ENDOCRINOLOGY (2007)
Differential effects of RGS proteins on G alpha(q) G alpha(11) activity
Graham Ladds et al.
CELLULAR SIGNALLING (2007)
Requirement of the TRPC1 cation channel in the generation of transient Ca2+ oscillations by the calcium-sensing receptor
Osvaldo Rey et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis
R. Mentaverri et al.
FASEB JOURNAL (2006)
Broad-spectrum L-amino acid sensing by class 3 G-protein-coupled receptors
Arthur D. Conigrave et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2006)
AMSH regulates calcium-sensing receptor signaling through direct interactions
Francisco Herrera-Vigenor et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases
Elizabeth Gray et al.
JOURNAL OF ENDOCRINOLOGY (2006)
N1-benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes:: Development of 4-chlorophenylcarboxamide (Calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity
Albane Kessler et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator
Jianxin Hu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly
Svetlana Pidasheva et al.
HUMAN MOLECULAR GENETICS (2006)
Calcium-sensing receptor abrogates secretagogue-induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction
John Geibel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Ca2+-sensing receptor induces Rho kinase-mediated actin stress fiber assembly and altered cell morphology, but not in response to aromatic amino acids
SL Davies et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
Calcium-sensing receptor stimulation induces nonselective cation channel activation in breast cancer cells
Yassine El Hiani et al.
JOURNAL OF MEMBRANE BIOLOGY (2006)
Activation of family C G-protein-coupled receptors by the tripeptide glutathione
MH Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats
Tobias Odenwald et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors
TK Bjarndóttir et al.
GENE (2005)
Identification of a novel extracellular cation-sensing G-protein-coupled receptor
M Pi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes
L Rodriguez et al.
ENDOCRINOLOGY (2005)
The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands
MM Dufner et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)
L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells
SM Busque et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)
A double mutation in the extracellular Ca2+-sensing receptor's Venus flytrap domain that selectively disables L-amino acid sensing
HC Mun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on serine 839 regulates Ca2+ oscillations
CH Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Amino acid-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor are mediated by a phospholipase C/inositol 1,4,5-trisphosphate-independent pathway that requires G12, Rho, Filamin-A, and the actin cytoskeleton
O Rey et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones
I Shcherbakova et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study
JY Reginster et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)
Chondrocyte calcium-sensing receptor expression is up-regulated in early guinea pig knee osteoarthritis and modulates PTHrP, MMP-13, and TIMP-3 expression
DW Burton et al.
OSTEOARTHRITIS AND CARTILAGE (2005)
β-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization
M Pi et al.
MOLECULAR ENDOCRINOLOGY (2005)
A novel calcium-sensing receptor antagonist transiently stimulates parathyroid hormone secretion in vivo
BJ Arey et al.
ENDOCRINOLOGY (2005)
Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism
M Colloton et al.
KIDNEY INTERNATIONAL (2005)
Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain
C Petrel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site
SU Miedlich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport
J VanHouten et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification
TA Hough et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
L-amino acids regulate parathyroid hormone secretion
AD Conigrave et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
pH sensing by the calcium-sensing receptor
SJ Quinn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
N1-arylsulfonyl-N2-(1-(1-naphthyl)ethyl)-1,2-diaminocyclohexanes:: A new class of calcilytic agents acting at the calcium-sensing receptor
A Kessler et al.
CHEMBIOCHEM (2004)
Extracellular calcium-sensing receptor transactivates the epidermal growth factor receptor by a triple-membrane-spanning signaling mechanism
RJ MacLeod et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
The Ca2+-sensing receptor couples to G alpha(12/13) to activate phospholipase D in Madin-Darby canine kidney cells
CF Huang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)
Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts
N Chattopadhyay et al.
ENDOCRINOLOGY (2004)
Role of the calcium-sensing receptor in parathyroid gland physiology
RA Chen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)
Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca2+-sensing receptor
C Petrel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Decreased expression of caveolin-1 and altered regulation of mitogen-activated protein kinase in cultured bovine parathyroid cells and human parathyroid adenomas
O Kifor et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells
J Tfelt-Hansen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)
Overexpression of the calcium sensing receptor accelerates epidermal differentiation and permeability barrier formation in vivo
K Turksen et al.
MECHANISMS OF DEVELOPMENT (2003)
Calcium and protein in bone health
B Dawson-Hughes
PROCEEDINGS OF THE NUTRITION SOCIETY (2003)
Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background
QS Tu et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors
H Ogata et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)
The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone
CH Kos et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation
O Fritze et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Activation of the MAP kinase cascade by exogenous calcium-sensing receptor
SA Hobson et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2003)
PTHrP stimulated by the calcium-sensing receptor requires MAP kinase activation
RJ MacLeod et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)
Molecular and functional characterization of the extracellular calcium-sensing receptor in human colon cancer cells
E Kallay et al.
ONCOLOGY RESEARCH (2003)
Vitamin D3 receptor ablation sensitizes skin to chemically induced tumorigenesis
GM Zinser et al.
CARCINOGENESIS (2002)
The dance of the clams:: twists and turns in the family C GPCR homodimer
AA Jensen et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2002)
L-amino acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism?
AD Conigrave et al.
EUROPEAN JOURNAL OF CLINICAL NUTRITION (2002)
Calcium-sensing receptor activation of Rho involves filamin and Rho-guanine nucleotide exchange factor
M Pi et al.
ENDOCRINOLOGY (2002)
Aminoglycoside antibiotics induce pH-sensitive activation of the calcium-sensing receptor
SJ McLarnon et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function
ZX Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
L-phenylalanine and NPS R-467 synergistically potentiate the function of the extracellular calcium-sensing receptor through distinct sites
ZX Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Association between activating mutations of calcium-sensing receptor and Bartter's syndrome
S Watanabe et al.
LANCET (2002)
Human calcium-sensing receptor gene - Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D
L Canaff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Polyvalent cation receptor proteins (CaRs) are salinity sensors in fish
J Nearing et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Physiological and pharmacological agonists of the extracellular Ca2+ sensing receptor
SJ McLarnon et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation
L Komuves et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2002)
Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor
CF Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human Ca2+ receptor
K Ray et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Management of disturbances of calcium and phosphate metabolism in chronic renal insufficiency, with emphasis on the control of hyperphosphataemia
F Locatelli et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2002)
Mitogen-activated protein kinase cascade in human normal and tumoral parathyroid cells
S Corbetta et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2002)
Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+
D Tsuchiya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation
WH Chang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Heterodimerization of calcium sensing receptors with metabotropic glutamate receptors in neurons
L Gama et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Molecular aspects in the regulation of renal inorganic phosphate reabsorption: the type IIa sodium/inorganic phosphate co-transporter as the key player
H Murer et al.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2001)
The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqα-dependent ERK-independent pathway
ME Handlogten et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions
ZX Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells
O Kifor et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2001)
Extracellular calcium sensing and extracellular calcium signaling
EM Brown et al.
PHYSIOLOGICAL REVIEWS (2001)
Comparison of hypocalcemic hypercalciuria between patients with idiopathic hypoparathyroidism and those with gain-of-function mutations in the calcium-sensing receptor: Is it possible to differentiate the two disorders?
M Yamamoto et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2000)
Extracellular Ca2+-sensing receptor is a promiscuous divalent cation sensor that responds to lead
ME Handlogten et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2000)
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor
N Kunishima et al.
NATURE (2000)
Functional interactions between the extracellular domain and the seven-transmembrane domain in Ca2+ receptor activation
OM Hauache et al.
ENDOCRINE (2000)
Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats
M Gowen et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
L-Amino acid sensing by the extracellular Ca2+-sensing receptor
AD Conigrave et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Cloning and characterization of two promoters for the human calcium-sensing receptor (CaSR) and changes of CaSR expression in parathyroid adenomas
N Chikatsu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Developmental and adult expression of rat calcium-sensing receptor transcripts in neurons and oligodendrocytes
S Ferry et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2000)
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