Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 252, Issue -, Pages 87-92Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2016.04.018
Keywords
Enrofloxacin; Reproductive toxicity; Supranutritional; Selenium
Funding
- University Grants Commission, India [42-631/2013]
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The study was designed to assess the ameliorative potential of selenium (Se) on enrofloxacin-induced testicular toxicity in rats. There was a significant decrease in body weight and non-significant decrease in mean testicular weight of enrofloxacin treated rats. In enrofloxacin treated rats, total sperm count and viability decreased where as sperm abnormalities increased. Testicular histopathology revealed dose dependent dysregulation of spermatogenesis and presence of necrotic debris in seminiferous tubules which was marginally improved with Se. Enrofloxacin also produced a dose dependent decrease in testosterone level. The activity of testicular antioxidant enzymes decreased where as lipid peroxidation increased in a dose-dependent manner. Se supplementation partially restored oxidative stress and sperm damage and did not affect the plasma concentrations of enrofloxacin or ciprofloxacain. The results indicate that enrofloxacin produces a dose-dependent testicular toxicity in rats that is moderately ameliorated with supranutritional Se. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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