Journal
CHEMICAL SOCIETY REVIEWS
Volume 45, Issue 23, Pages 6488-6519Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cs00616g
Keywords
-
Categories
Funding
- Shenzhen University
- National Science Foundation of China [81401465, 51573096, 51602203]
- Postdoctoral Science Foundation of China [2016M590808]
- Intramural Research Program (IRP) of the NIBIB, NIH
Ask authors/readers for more resources
Photodynamic therapy (PDT) has been applied to treat a wide range of medical conditions, including wet age-related macular degeneration psoriasis, atherosclerosis, viral infection and malignant cancers. However, the tissue penetration limitation of excitation light hinders the widespread clinical use of PDT. To overcome this Achilles'heel'', deep PDT, a novel type of phototherapy, has been developed for the efficient treatment of deep-seated diseases. Based on the different excitation sources, including near-infrared (NIR) light, X-ray radiation, and internal self-luminescence, a series of deep PDT techniques have been explored to demonstrate the advantages of deep cancer therapy over conventional PDT excited by ultraviolet-visible (UV-Vis) light. In particular, the featured applications of deep PDT, such as organelle-targeted deep PDT, hypoxic deep PDT and deep PDT-involved multimodal synergistic therapy are discussed. Finally, the future development and potential challenges of deep PDT are also elucidated for clinical translation. It is highly expected that deep PDT will be developed as a versatile, depth/oxygen-independent and minimally invasive strategy for treating a variety of malignant tumours at deep locations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available