Synthesis of alpha-aminoboronic acids

This review describes available methods for the preparation of alpha-aminoboronic acids in their racemic or in their enantiopure form. Both, highly stereoselective syntheses and asymmetric procedures leading to the stereocontrolled generation of alpha-aminoboronic acid derivatives are included. The preparation of acyclic, carbocyclic and azacyclic alpha-aminoboronic acid derivatives is covered. Within each section, the different synthetic approaches have been classified according to the key bond which is formed to complete the alpha-aminoboronic acid skeleton.