Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 24, Issue 10, Pages 2139-2146Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.0c00185
Keywords
photochemistry; photocycloaddition; continuous manufacturing; flow chemistry
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This article details the approach to large-scale production of cyclobutane 2 by the continuous-flow [2 + 2] photocycloaddition of maleic anhydride and ethylene, including (1) focused reaction optimization and development of a robust isolation protocol, (2) the approach to equipment design and process safety, and (3) the results of commissioning tests and production runs delivering the target compound at throughputs exceeding 5 kg/day.
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