Journal
ORGANIC LETTERS
Volume 22, Issue 11, Pages 4553-4556Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01615
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Funding
- National Natural Science Foundation of China [21922109, 21672196, 21602001, 21831007]
- Nanjing Tech University [39837134]
- Fundamental Research Funds for the Central Universities of China [WK2060190086]
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A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramolecular coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.
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