Journal
ORGANIC LETTERS
Volume 22, Issue 10, Pages 3960-3963Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01243
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Funding
- NSF under the CCI Center for Selective C-H Functionalization [CCHE-1700982]
- Scripps Research Institute
- Bristol-Myers Squibb
- NIH [1S10OD025208]
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Pd(II)-catalyzed C-H lactonization of o-methyl benzoic acid substrates has been achieved using molecular oxygen as the oxidant. This finding provides a rare example of C-H oxygenation through Pd(II)/Pd(0) catalysis as well as a method to construct biologically important benzolactone scaffolds. The use of a gas mixture of 5% oxygen in nitrogen demonstrated the possibility for its application in pharmaceutical manufacturing.
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