4.8 Article

Total Synthesis of (±)-Thebainone A by Intramolecular Nitrone Cycloaddition

Journal

ORGANIC LETTERS
Volume 22, Issue 8, Pages 3145-3148

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00905

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Funding

  1. Deutsche Forschungsgemeinschaft [ME 776/22-1]

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Using an intramolecular nitrone cycloaddition and a Heck cyclization as the crucial transformations, a total synthesis of the racemic morphine alkaloid thebainone A was accomplished in 22 steps commencing with isovanillin.

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