Journal
ORGANIC LETTERS
Volume 22, Issue 8, Pages 2995-2998Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00746
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Funding
- NSFC [81820108030]
- National Research, Development and Innovation Office [K120181]
- Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences
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Alternarin A (1), a rearranged drimane meroterpenoid characterized by a thioglycerate moiety, was isolated together with two known analogues from the coral-associated fungi Alternaria sp. ZH-IS. Its structure was determined based on spectroscopic analysis, modified Mosher's method, and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, compound 1 effectively inhibited the activity of spontaneous synchronous Ca2+ oscillations and 4-aminopyridine induced epileptic discharges in the low micromolar concentration range.
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