4.8 Article

Gold and Bronsted Acid Catalyzed Spirocyclization of 2-and 3-Indolyl-Tethered 1,4-Enyne Acetates to Spiro[4,n]alkyl[b]indoles

Journal

ORGANIC LETTERS
Volume 22, Issue 7, Pages 2849-2853

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00929

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Funding

  1. Australian Research Council [DP160101682]
  2. [21602148]

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A synthetic method to prepare spiro[4,n]alkyl[b]indoles (n = 4-6) efficiently that relies on the gold(I) and Bronsted acid mediated spirocyclization of 2- and 3-indolyl-tethered 1,4-enyne acetates at room temperature and open to air is described.

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