Journal
ORGANIC LETTERS
Volume 22, Issue 7, Pages 2776-2780Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00761
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Funding
- CAPES foundation
- University of Nottingham
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A versatile method for the synthesis of enantioen-riched N-H sulfoximines is reported. The approach stems from the organomagnesium-mediated ring opening of novel cyclic sulfonimidate templates. The reactions proceed in high yield and with excellent stereofidelity with alkyl, aryl, and heteroaryl Grignard reagents. The chiral auxiliary is readily removed from the resultant sulfoximines via an unusual oxidative debenzylation protocol that utilizes molecular oxygen as the terminal oxidant. This provides a general strategy for the synthesis of highly enantioenriched N-H sulfoximines.
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