Journal
ORGANIC LETTERS
Volume 22, Issue 7, Pages 2663-2668Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00631
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Funding
- Jiangsu Province [BK20181066, 18KJD150002]
- National Natural Science Foundation of China [21762002]
- Huaiyin Normal University JSKLCLDM [JSKC18014]
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We report a chelation-assisted C-H arylation of various indoles with sterically and electronically diverse (hetero)arylsilanes enabled by cost-effective Cp*-free cobalt catalysis. Key to the success of this strategy is the judicious choice of copper(II) fluoride as a bifunctional sliane activator and catalyst reoxidant. This methodology features a broad substrate scope and good functional group compatibility. The synthetic versatility of this protocol has been highlighted by the gram-scale synthesis and late-stage diversification of biologically active molecules.
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