Journal
OPTICS LETTERS
Volume 45, Issue 8, Pages 2168-2171Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.387747
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Funding
- National Science Foundation [DMR 1548924]
- Herbert Wertheim College of Medicine, Florida International University (H. and N. Wertheim Professorship Endowment)
- NSF [NSF.EEC-1648451]
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Reflectance Mueller matrix (MM) polarimetry is being used to characterize biological media in multiple clinical applications. The origin of the reflectance polarimetric data is often unclear due to the impact of multiple scattering and tissue heterogeneity. We have developed a new, to the best of our knowledge, multi modal imaging technique combining MM reflectance, MM digital confocal imaging, and co-registered nonlinear microscopy techniques. The instrument unveils the origin of reflectance polarimetric signature in terms of confocal reflectance data. The reconstructed reflected. MM demonstrates the capability of our method to provide depth-resolved 3D polarization response from complex biological media in terms of depolarization, retardance, and orientation parameters. (C) 2020 Optical Society of America
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