Journal
CHEMICAL REVIEWS
Volume 117, Issue 8, Pages 5367-5388Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.6b00578
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Funding
- National Institutes of Health [NIH GM040541]
- Welch Foundation [Welch F-1511]
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[4 + 2]-Cycloadditions are increasingly being recognized in the biosynthetic pathways of many structurally complex natural products. A relatively small collection of enzymes from these pathways have been demonstrated to increase rates of cyclization and impose stereochemical constraints on the reactions. While mechanistic investigation of these enzymes is just beginning, recent studies have provided new insights with implications for understanding their biosynthetic roles, mechanisms of catalysis, and evolutionary origin.
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