Journal
CHEMICAL REVIEWS
Volume 116, Issue 4, Pages 2664-2704Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.5b00465
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Funding
- Cornell Center for Materials Research
- Cornell Center for Advanced Technology, Boston University
- Coulter Foundation
- Pew Foundation
- National Science Foundation
- National Institutes of Health
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The utility of metabolic synthons as the building blocks for new biomaterials is based on the early application and success of hydroxy acid based polyesters as degradable sutures and controlled drug delivery matrices. The sheer number of potential monomers derived from the metabolome (e.g., lactic acid, dihydroxyacetone, glycerol, fumarate) gives rise to almost limitless biomaterial structural possibilities, functionality, and performance characteristics, as well as opportunities for the synthesis of new polymers. This review describes recent advances in new chemistries, as well as the inventive use of traditional chemistries, toward the design and synthesis of new polymers. Specific polymeric biomaterials can be prepared for use in varied medical applications (e.g., drug delivery, tissue engineering, wound repair, etc.) through judicious selection of the monomer and backbone linkage.
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