Journal
CHEMICAL REVIEWS
Volume 116, Issue 16, Pages 9001-9090Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.6b00220
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Funding
- Ontario Research Fund through the Ministry of Research and Innovation
- Canadian Institutes for Health Research
- Canadian Cancer Society Research Institute [702414]
- Ontario Research Fund
- Natural Sciences and Engineering Council of Canada
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Rapid progress in identifying biomarkers that are hallmarks of disease has increased demand for high-performance detection technologies. Implementation of electrochemical methods in clinical analysis may provide an effective answer to the growing need for rapid, specific, inexpensive, and fully automated means of biomarker analysis. This Review summarizes advances from the past 5 years in the development of electrochemical sensors for clinically relevant biomolecules, including small molecules, nucleic acids, and proteins. Various sensing strategies are assessed according to their potential for reaching relevant limits of sensitivity, specificity, and degrees of multiplexing. Furthermore, we address the remaining challenges and opportunities to integrate electrochemical sensing platforms into point-of-care solutions.
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