Journal
OBESITY
Volume 28, Issue 9, Pages 1586-1589Publisher
WILEY
DOI: 10.1002/oby.22907
Keywords
-
Categories
Funding
- NIHR Manchester Biomedical Research Centre
- North West Lung Centre Charity, Manchester
Ask authors/readers for more resources
Objective Mortality from coronavirus disease 2019 (COVID-19) is increased in patients with chronic obstructive pulmonary disease (COPD). Furthermore, higher BMI is related to severe disease. Severe acute respiratory syndrome coronavirus 2 utilizes angiotensin converting enzyme 2 (ACE2) to gain cellular entry. Methods Whether ACE2 bronchial epithelial expression is increased in COPD patients who have overweight compared with those who do not was investigated by RNA sequencing. Results Increased ACE2 expression was observed in patients with COPD with overweight (mean BMI, 29 kg/m(2)) compared with those without overweight (mean BMI, 21 kg/m(2)) (P = 0.004). Conclusions Increased ACE2 expression may cause increased severe acute respiratory syndrome coronavirus 2 infection of the respiratory tract. Overweight COPD patients may be at greater risk for developing severe COVID-19.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available