Journal
ACTA PHARMACOLOGICA SINICA
Volume 37, Issue 1, Pages 19-24Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/aps.2015.109
Keywords
transient receptor potential channel C5; cancer chemoresistance; drug target
Funding
- China National Natural Science Foundation [81572940, 91439131, 31200126]
- Natural Science Foundation for Distinguished Young Scholars of Jiangsu Province [BK20140004]
- Program for New Century Excellent Talents in University of The Ministry of Education of China [NCET-12-0880]
- National High Technology Research and Development Program (863 Program) of China [SQ2015AA020948]
- Fundamental Research Funds for Central Universities [JUSRP51311A, JUSRP51519]
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The transient receptor potential (TRP) superfamily contains at least 28 homologs in mammalian. These proteins form TRP channels are permeable to monovalent and divalent cations and participate in a variety of physiological functions. Dysregulation of TRP channels is responsible for numerous diseases. This review provides a brief short overview of mammalian TRP channels with a focus on TRPC5 and its role in cancers. Dysregulation of TRPC5 interrupts Ca2+ homeostasis in cancer cells, which activates signaling pathways that are highly associated with cancer progression, especially cancer chemoresistance. Based on the important role of TRPC5, we also discuss the potential of TRPC5 as a target for therapeutic intervention. Either direct targeting of TRPC5 or indirect interruption of TRPC5-related signaling pathways may effectively overcome cancer chemoresistance.
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