Journal
NEW PHYTOLOGIST
Volume 227, Issue 2, Pages 295-310Publisher
WILEY
DOI: 10.1111/nph.16562
Keywords
bioengineering; metabolic engineering; plant biotechnology; plant synthetic biology; protein engineering
Categories
Funding
- UK Biotechnology and Biological Sciences
- Engineering and Physics Research Council (BBSRC) synthetic biology for growth programme (OpenPlant Synthetic Biology Research Centre) [BB/L014130/1]
- Engineering and Physics Research Council (EPSRC) synthetic biology for growth programme (OpenPlant Synthetic Biology Research Centre) [BB/L014130/1]
- BBSRC [BBS/E/T/000PR9815, BB/P010490/1, BB/S020853/1, BB/R021554/1]
- BBSRC [BB/M000966/1, BB/R021554/1, BB/P010490/1, BB/S020853/1, BBS/E/T/000PR9818, BBS/E/T/000PR9819, BB/L014130/1] Funding Source: UKRI
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Powered by developments that enabled genome-scale investigations, systems biology emerged as a field aiming to understand how phenotypes emerge from network functions. These advances fuelled a new engineering discipline focussed on synthetic reconstructions of complex biological systems with the goal of predictable rational design and control. Initially, progress in the nascent field of synthetic biology was slow due to the ad hoc nature of molecular biology methods such as cloning. The application of engineering principles such as standardisation, together with several key technical advances, enabled a revolution in the speed and accuracy of genetic manipulation. Combined with mathematical and statistical modelling, this has improved the predictability of engineering biological systems of which nonlinearity and stochasticity are intrinsic features leading to remarkable achievements in biotechnology as well as novel insights into biological function. In the past decade, there has been slow but steady progress in establishing foundations for synthetic biology in plant systems. Recently, this has enabled model-informed rational design to be successfully applied to the engineering of plant gene regulation and metabolism. Synthetic biology is now poised to transform the potential of plant biotechnology. However, reaching full potential will require conscious adjustments to the skillsets and mind sets of plant scientists.
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