Journal
NEW ENGLAND JOURNAL OF MEDICINE
Volume 382, Issue 17, Pages 1653-1659Publisher
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMsr2005760
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The effects of renin-angiotensin-aldosterone system blockers on angiotensin-converting enzyme 2 levels and activity in humans are uncertain. The authors hypothesize that ACE2 may be beneficial rather than harmful during lung injury and suggest that RAAS-inhibitor withdrawal may be harmful in some high-risk patients with known or suspected Covid-19.
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