Wnt/β-Catenin Signaling in Neural Stem Cell Homeostasis and Neurological Diseases

Neural stem/progenitor cells (NSCs) maintain the ability of self-renewal and differentiation and compose the complex nervous system. Wnt signaling is thought to control the balance of NSC proliferation and differentiation via the transcriptional coactivator beta-catenin during brain development and adult tissue homeostasis. Disruption of Wnt signaling may result in developmental defects and neurological diseases. Here, we summarize recent findings of the roles of Wnt/beta-catenin signaling components in NSC homeostasis for the regulation of functional brain circuits. We also suggest that the potential role of Wnt/beta-catenin signaling might lead to new therapeutic strategies for neurological diseases, including, but not limited to, spinal cord injury, Alzheimer's disease, Parkinson's disease, and depression.

Automated summary

The Wnt/beta-catenin signaling pathway plays a crucial role in regulating the balance of neural stem/progenitor cells (NSCs) proliferation and differentiation, which is essential for the development and maintenance of the nervous system. Recent findings suggest that components of the Wnt/beta-catenin signaling pathway are involved in the regulation of functional brain circuits, providing potential therapeutic targets for neurological diseases.